In a pioneering study, researchers from Harvard Medical School, University of Maine, and MIT have introduced a chemical method for reversing cellular aging. This revolutionary approach offers a potential alternative to gene therapy for age reversal. The findings could transform treatments for age-re

Age Reversal Breakthrough: Harvard/MIT Discovery Could Enable Whole-Body Rejuvenation::In a pioneering study, researchers from Harvard Medical School, University of Maine, and MIT have introduced a chemical method for reversing cellular aging. This revolutionary approach offers a potential alternative to gene therapy for age reversal. The findings could transform treatments for age-re

  • belshamharoth@lemmy.worldEnglish
    8·
    1 year ago

    The full journal article says “in vivo” not “in vitro”. They have already successfully regenerated mice which are organisms biologically similar to humans.

    Edit

    I was wrong about this. The journal article does only talk about results obtained “in vitro” but mentions other studies that have successfully reversed cellular ageing “in vivo”.

    The ability of the Yamanaka factors to erase cellular identity raised a key question: is it possible to reverse cellular aging in vivo without causing uncontrolled cell growth and tumorigenesis? Initially, it didn’t seem so, as mice died within two days of expressing OSKM. But work by the Belmonte lab, our lab, and others have confirmed that it is possible to safely improve the function of tissues in vivo by pulsing OSKM expression [22, 23] or by continuously expressing only OSK, leaving out the oncogene c-MYC

    So in this study the results were only in vitro but other studies have successfully reversed cellular ageing in vivo.

    • Sekrayray@lemmy.worldEnglish
      1·
      1 year ago

      Yeah it was confusing and I had to read the source article a couple of times. If I’m recalling correctly I think the mouse model they’re referring to used gene splicing to reverse aging in-vivo—which to my understanding is a hell of a lot riskier and invasive than a molecular/biochemical based technique as described by the primary researchers (but only done in vitro). I would’ve been impressed if they used a biochemical technique in vivo because that would mean they had solved an issue of drug delivery, which is the thing that’ll halt the progress of this stuff becoming mainstream.