As far as the pineal gland goes, a book written in 2000 (DMT: The Spirit Molecule) declares the pineal gland produces enough DMT (Dimethyltryptamine) to experience hallucinogenic effects but this has not been confirmed, trace amounts of DMT has been found in the pineal glands of rats, but not humans. If there was enough DMT in a pineal gland and you ate it, you would also need to inhibit certain enzymes that break it down, namely, Monoamine Oxidase.
Come and goes for me, I try to play only one RPG or adventure type game at a time to remain hooked to the plot, several hours into Final Fantasy 8 on steam at the moment, played Xenogears on my steamdeck using emulation before it. I’m in my thirties for reference.