Katalin Karikó and Drew Weissman.
They noticed that naively adding test tube synthesized mRNA elicited immflamatory responses from immune cells, while mRNA derived from cells did not. They figured out that chemical modifications to mRNAs were responsible for avoiding these immune reactions to the mRNAs.
These results would open the path for development of mRNA-based vaccines, like the vaccines repsonsible for limiting the damage of the COVID-19 pandemic.
https://www.nobelprize.org/prizes/medicine/2023/press-release/
I think you might have skimmed over the methods, but think what the OP was trying to say is:
Concentration: 300 tea bags / 600mL = 1 teabag per 2mL (175 tea bags in one 350mL cup of tea, doesnt appear typical?)
Mixing: 750rpm × [1m/60s] = 12.5 rotations a sec (Awfully fast to be stirring tea, constantly)
Incubation time: Not specified. (They could have left boiling overnight?)
There seems to be many points about the methodology that raise eyebrows. Maybe it’s ok if you want to use this method to purify particles for structural analysis or test toxicity on cells, but it doesn’t seem fair to present this as “release of micro/nanoplastics (MNPLs) from polymer-based teabags into the aqueous phase during typical usage”, as the amounts seem exaggerated.